The Scientist reports here that new mathematical studies refute previous findings that most current published medical research findings are false due to small study sizes and bias. I suppose–considering the original assertion of “most” announced discoveries being wrong–we can literally live with a false positive rate of ‘only’ 14% for findings that relate ultimately to our well being. But the best advice is:
It is still important to report estimates and confidence intervals in addition to or instead of p-values when possible so that both statistical and scientific significance can be judged by readers.
– Leah R. Jager, Jeffrey T. Leek (“Empirical estimates suggest most published medical research is true”)